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Human gastrointestinal microbiota, also referred to as gut flora or gut microbiota, comprise the diverse microorganisms residing within the human digestive tract. A healthy gut microbiota typically consists of approximately 80% beneficial bacteria, which play a crucial role in maintaining overall health.
Probiotics support the body in maintaining an optimal balance between beneficial and potentially harmful bacteria. Scientific research indicates that poor intestinal health, often resulting from an imbalance in the gut microbiota and an overgrowth of pathogenic bacteria, is associated with the development of various chronic health conditions:
Examples of the problems associated with poor gut health
- Unhealthy weight - Obesity, Overweight
- Poor Immunity - Fall sick regularly
- Poor skin condition - Acne, Eczema, Skin flares
- Poor mental health - Lethargic, tired regularly, difficulty remembering
- Irregular Bowels - Difficulty moving bowels, Poor digestive health
- Stomach Discomfort - Pain in stomach
- Bad Breath - Especially in the mornings, built up of bad bacteria
Our Everyday Lifestyle can cause havoc to our health
- High sweet intake - Can cause bad bacteria to repopulate faster
- High alcohol consumption- High alcohol can destroy good bacteria and alter the microbial balance of bacteria.
- Lack of sleep, rest and increase stress - Affects microbial diversity
- Frequent use of antibiotics - Destroys all good and bad bacteria, affects the gut flora diversity greatly Pollution and tainted food sources - Alter the gut microbial diversity
- Unfiltered water with chemicals - Can affect microbial balance of bacteria
- Smoking - Causes lung and colon cancer
The type of probiotic strains selected and used in combination is important in improving digestive and immune health.
1. Lactobacillus La-14: is a lactic acid bacterium of human origin that has been documented in over 50 scientific studies, including 18 clinical trials. Preclinical studies have shown La-14 can impact both the innate and adaptive immune system.
Has excellent properties in helping to relieve diarrhoea, IBS, constipation and promote better digestive health. Preclinical studies have shown La-14 can impact both the innate and the adaptive immune system. Wickens K, et al. BJN. 2017;117(6):804-813. Slykerman RF, et al. EBioMedicine. 2017;24:159-165.
2. Lactobacillus plantarum R-1012 - Has excellent properties in helping prevent / relieve stomach problems. Relieve IBS, a study has shown when combined with L.acidophillus there is a 45% improvement in helping treat chronic and delibitating inflammatory diseases.
3. Bifidobacterium longum BI-05 - Helps prevent/relieve stomach problems - Bifidobacterium may play an important role in treating diarrhoea. Helps relieve IBS
Bifidobacterium longum has anti-inflammatory effects on intestinal diseases and building strong immune function. Bifidobacterium longum can effectively improve the symptoms of IBD. Promotes better gut health.
4. Enterococcus faecalis CEC-0411 - well-suited to the intestinal environment to help reduce inflammation. Helps prevent/relieve stomach problems, helps relieve IBS , helps relieve AAD, helps relieve Constipation. It is a safe and useful probiotic for the treatment of abdominal pain in patients with IBS.
5. Lactobacillus rhamnosus MG-316 - Promotes better gut health, showed high antioxidant activities ranging from 22.2% to 38.2% in DPPH free radical scavenging. It is resistant to simulated gastric (pH 3 and 4) and intestinal fluids (pH 7 and 8), and showed potential for the promotion of health based on hemolysis, auto-aggregation, antibiotic susceptibility, enzyme production, and biochemical profiles.
6. Latilactobacillus sakei K040706 - A single strain of probiotics isolated from soybean paste, a traditional Korean fermented food. This is strain of bacteria that has been shown to have immunostimulatory and anti-inflammatory properties. One of the best immunity probiotic strain in Korea.
How does probiotics help you to achieve a healthy gut flora?
Probiotics are beneficial microorganisms that confer health advantages to the host. When consumed in sufficient quantities, they contribute to digestive tract health by restoring and maintaining a balanced gut microbiota, replacing harmful bacteria along the gastrointestinal walls.
In the absence of beneficial bacteria, pathogenic bacteria may colonise the intestinal lining. Probiotics enhance nutrient and vitamin absorption and assist in the elimination of toxic compounds from the digestive system. Ensuring an adequate intake of appropriate probiotic strains is essential for sustaining a healthy gut flora.
Why is your gastrointestinal tract important?
Microorganisms collectively referred to as the microbiome reside in the gastrointestinal tract and comprise bacteria, fungi, and viruses. Gut bacteria are involved in various physiological processes, including immune system function, serotonin synthesis, energy extraction from food, and the metabolism of foreign substances and toxins.
What happens when your gastrointestinal tract has too much bad bacteria?
Diarrhoea, constipation, bloating, nausea, and heartburn are classic symptoms of problems with gut health. Skin problems, increase in anxiety, weight increases, etc...sometimes it might lead to chronic diseases such as colon problems.
What is the job of probiotics to help prevent or improve our gastrointestinal condition?
Probiotics are made of good live bacteria that naturally live in your body. You constantly have both good and bad bacteria in your body. When you get an infection or fall sick, there’s more bad bacteria, knocking your system out of balance.
Good bacteria helps replace and eliminate extra bad bacteria, returning the GI balance. Probiotic-supplements are a way to add good bacteria to your body.
The main job of probiotics, or good bacteria, is to maintain a healthy balance in your body. Think of it as keeping your body in neutral. When you are sick, bad bacteria enters your body and increases in number. This knocks your body out of balance.
Good bacteria works to fight off the bad bacteria and restore the balance within your body, making you feel better. Good bacteria keeps you healthy by supporting your immune function and controlling inflammation. Good probiotics will target your gut problem, by helping to break down food faster and help the body absorb nutrients easier. Therefore improving your health.
See the Importance of maintaining 80% good bacteria balance in your body!
Promoting Better Digestive Health Let's be honest.
Digestive issues such as occasional upset stomach, gas, bloating, or diarrhoea can significantly impact quality of life. These symptoms are often associated with an imbalance of beneficial bacteria within the digestive tract.
Lactomin Advance + contains probiotics formulated to help restore the natural balance of beneficial bacteria in the intestines, thereby supporting optimal digestive function and overall well-being.
Why Lactomin advance+ Probiotics
Lactomin advance + probiotics contains six specific strains that function collectively to support digestion and immune health. These strains may assist with digestive concerns such as IBS, AAD, traveller's diarrhoea, diarrhoea, constipation, and bloating.
Digestive health is closely linked to overall health, as the digestive tract plays a central role in processing nutrients and supporting immune system function.
So, how can you help support these vital functions and boost overall digestion?
Lactomin Advance + probiotics contain six specific strains that work together to support digestion and immune health. These strains may help address digestive concerns such as IBS, AAD, traveller's diarrhoea, diarrhoea, constipation, and bloating.
Digestive health is closely related to overall well-being, as the digestive system is involved in processing nutrients and assisting immune system function.
To help maintain these functions and support digestion, it is possible to use daily probiotics like Lactomin. Lactomin probiotics provide a combination of beneficial bacteria.
The human body contains billions of bacteria, many of which are concentrated in the digestive tract.
While many of these bacteria exist harmoniously within the body, an imbalance caused by non-beneficial bacteria may disrupt the gastrointestinal environment. Probiotic supplements can be used to support this balance.
Research indicates that probiotics may help reduce occasional digestive issues like gas, bloating, and diarrhoea by supporting the natural balance of beneficial and non-beneficial bacteria in the digestive tract. Since a significant portion of the immune system is located in the digestive tract, maintaining balance in the digestive system may also support immune health.
When taken regularly, a probiotic such as Lactomin Advance + may support digestive system function.
Lactomin Advance + includes vitamins B and D in addition to probiotics:
• Vitamins B1 and B2: Support energy production and influence enzymes affecting muscles, nerves, and the heart.
• Vitamin B5: Contributes to fat and carbohydrate breakdown for energy and supports skin health.
• Vitamin B6: Assists with protein metabolism and maintains red blood cell, nervous system, and immune system health.
• Vitamin B9: Supports red blood cell production.
• Vitamin D3: Aids the use of calcium and phosphorus for bone and dental health.
Probiotics have become increasingly popular in Singapore, and in recent years, they have become one of the most searched health supplements in the country.
Why each Lactomin sachet produces results?
70% of the body's immune system is managed in the gut. It supports your immunity by stimulating the body's natural defences in the gut.
A layer of beneficial bacteria lines the intestines, contributing to the balance between helpful and harmful microorganisms in the digestive tract. This is important for maintaining normal digestive system function.
Clinical studies have evaluated Lactomin Advance + for its effects on digestive health. Research suggests it may help relieve stomach upset and constipation, as well as reduce gas and stomach bloating.
It is formulated to support digestion and immune function.
Lactomin Advance + probiotics are intended for adults and older children. The product is made from natural ingredients and has obtained GMP certification from the Korea Food and Drug Administration (KFDA).
It is manufactured in Korea and used internationally.
Lactomin Advance + contains a patented blend of Lactobacillus acidophilus La-14, Bifidobacterium longum BI-05, and Streptococcus faecalis CEC-0411, with the addition of Lactobacillus rhamnosus MG-316, Lactobacillus plantarum R-1012, and Latilactobacillus sakei K040706.
The formulation also includes vitamins B1, B2, B5, B6, B9, D3, and prebiotics.
It is proven probiotics can influence immunity
The addition of the 6th strain (Latilactobacillus sakei K040706) have clinical studies supporting it as an immunity bacteria, stimulating immune cell production and improves intestinal inflammation.
Probiotic bacteria can interact and stimulate intestinal immune cells and commensal microflora to modulate specific immune functions and immune homeostasis. Growing evidence shows that probiotic bacteria present important health-promoting and immunomodulatory properties.
Thus, the use of probiotics might represent a promising approach for improving immune system activities. The intestine is considered the largest immunological organ as it contains approximately 70–80% of all IgA-producing B cells.
IgAs are proteolytic-resistant antibodies locally synthesized in effector tissues which, in turn, are particularly important in the mucosal membrane immune function. The mucosal immunological function of IgAs is to provide protection for mucosal surfaces, by binding to and neutralizing foreign antigens from pathogenic agents/toxins.
IgAs therefore inhibit microorganism adhesion to intestinal epithelial cells and subsequent penetration. However, recent evidence suggests that IgAs are emerging as inflammation players, both at mucosal and non-mucosal sites.
Two distinct immune responses, i.e., innate and adaptive immunities, synergistically work together in the gut to protect organisms against pathogens. Several beneficial effects of probiotics, on the intestinal homeostasis, have been reported, such as (i) amelioration of innate and adaptive immune responses and related anti-pathogenic/inflammatory activities, (ii) enhancement of bioavailability of certain natural or metabolic components and essential nutrients, and (iii) food intolerance decrease among susceptible subjects.
In other words, similar to gut commensal microbiota,
Consumed probiotics have been shown to positively affect the entire organism by improving digestion and immunity. Source: National Library of medicine PMCID: PMC9818925
The unique Lactomin (MCC) probiotic delivery process
Why survivability of probiotics are so important and why Lactomin's MCC is assures >90% of probiotic strains reaches the intestinal area?
The viability of probiotics in natural environments is significantly affected by factors such as temperature, humidity, and exposure to stomach acids. Consumer information typically emphasises the quantity of probiotics, often measured in billions, rather than their survivability through the digestive tract.
However, a high probiotic count does not necessarily guarantee effective gut absorption; for example, it is possible to ingest 100 billion probiotic cells but absorb less than 2% if the strains are unprotected, as the majority are unable to survive passage through the stomach.
Additional considerations impacting probiotic survival include temperature stability, strain quality, storage conditions, and humidity. Studies indicate that approximately 59% of probiotic strains may perish due to suboptimal storage or fluctuating environmental conditions.
Even encapsulated probiotics require proper handling to maintain efficacy. When capsules are opened prior to consumption, lactic acid bacteria can be exposed to air and may quickly lose viability.
Furthermore, given the considerable length of the human intestinal tract—comparable to a double-decker bus—it is essential that probiotic strains are adequately protected to reach the intestines and traverse the intestinal walls successfully.
This dual-layer system effectively safeguards each probiotic strain against temperature fluctuations, humidity, and exposure to acidic conditions in the stomach. It is capable of withstanding storage temperatures up to 35°C, whereas most probiotic products require storage at or below 25°C.
In regions with consistently warm and humid climates, such as Singapore or Southeast Asia, maintaining temperatures below 25°C is challenging without refrigeration or climate control.
The MCC Double Coating employs a uniquely safe and natural protective barrier composed of organic materials.
This coating serves as a physical shield, protecting probiotic strains from both physiological and environmental stresses. By ensuring targeted release of the probiotics within specific areas of the intestine, it optimises strain delivery, enhances intestinal colonisation, and supports the health of the intestinal lining.
Bifidobacterium demonstrates optimal growth from birth through early childhood, but its abundance decreases significantly with advancing age. It is essential to maintain sufficient levels of bifidobacteria in the body to derive their substantial health benefits.
The intestinal microbiota has been increasingly recognized for its critical role across multiple aspects of human health. Within the extensive gut bacterial community, Bifidobacterium is a predominant genus in the intestines of healthy breast-fed infants; however, its levels decrease in adulthood.
The distribution of various bifidobacterial species shifts throughout the life cycle, from childhood through old age. Emerging evidence highlights the positive impact of bifidobacteria supplementation on numerous health outcomes, including enhanced protection against infections and beneficial extra- and intra-intestinal effects.
Bifidobacterium contributes significantly to the barrier function of the gut and the stimulation of the immune system, supporting a broad spectrum of health advantages. After birth, bifidobacterial concentrations are at their highest—particularly following natural delivery—and tend to be lower in infants delivered via Caesarean section.
Reduced bifidobacteria levels have been associated with conditions such as obesity, diabetes, and allergies at different stages of life. As children transition to solid foods, dietary factors become more influential, resulting in the development of a stable, adult-like microbiota.
The accompanying figure in Voreades et al. (2014) reviews literature regarding the relative abundance of bifidobacteria at different life stages. Numerous strains of Bifidobacterium have demonstrated health-promoting effects when used as probiotics in interventions targeting various adverse health conditions.
Furthermore, bifidobacteria's ability to modulate the immune system appears to be species-specific. For example, research by Ménard et al. (2008) revealed that B. bifidum, B. dentium, and B. longum can stimulate both systemic and intestinal immunity. Due to their dominance in the infant gut, bifidobacteria are widely employed as probiotics for treating and preventing infant diseases.
Consequently, products such as Lactomin, Lactokids, and Lactocran incorporate bifidobacterium strains to provide robust probiotic benefits.
10 Critical and Essential areas to look out for in a good probiotic brand.
Quality of strains
Lactomin Media -
Review by Dawn Sim
Review by Davis Heng
Why good health matters?